DFTD: A Contagious Fatal Cancer that Threatens the Tasmanian Devils
نویسندگان
چکیده
منابع مشابه
DFTD: A Contagious Fatal Cancer that Threatens the Tasmanian Devils
The fact that Tasmanian devils are prone to a bizarre type of contagious facial cancer disease was first noted in 1996 in the far north east of Tasmania, and since then, the disease has spread south and west and now affects devils in over 85% of their distribution territory [1,2]. The disease, termed devil facial tumor disease (DFTD), is spread by biting, causing the appearance of tumors on the...
متن کاملMHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.
Tasmanian devils face extinction owing to the emergence of a contagious cancer. Devil facial tumour disease (DFTD) is a clonal cancer spread owing to a lack of major histocompatibility complex (MHC) barriers in Tasmanian devil populations. We present a comprehensive screen of MHC diversity in devils and identify 25 MHC types and 53 novel sequences, but conclude that overall levels of MHC divers...
متن کاملA second transmissible cancer in Tasmanian devils.
Clonally transmissible cancers are somatic cell lineages that are spread between individuals via the transfer of living cancer cells. There are only three known naturally occurring transmissible cancers, and these affect dogs, soft-shell clams, and Tasmanian devils, respectively. The Tasmanian devil transmissible facial cancer was first observed in 1996, and is threatening its host species with...
متن کاملThe pathology of devil facial tumor disease (DFTD) in Tasmanian Devils (Sarcophilus harrisii).
A disfiguring and debilitating neoplastic condition known as devil facial tumor disease (DFTD) has been discovered in wild Tasmanian Devils (Sarcophilus harrisii) across 51% of its natural range, with population declines of up to 80% in some areas (C. Hawkins, personal communication). Between 2001 and 2004, 91 cases were examined. The tumors presented as large, solid, soft tissue masses usually...
متن کاملDemonstration of immune responses against devil facial tumour disease in wild Tasmanian devils
Devil facial tumour disease (DFTD) is a recently emerged fatal transmissible cancer decimating the wild population of Tasmanian devils (Sarcophilus harrisii). Biting transmits the cancer cells and the tumour develops in the new host as an allograft. The literature reports that immune escape mechanisms employed by DFTD inevitably result in host death. Here we present the first evidence that DFTD...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical & Cellular Immunology
سال: 2016
ISSN: 2155-9899
DOI: 10.4172/2155-9899.1000e118